While celiac disease and MTHFR gene mutations are not directly related, they can both contribute to folate deficiency and elevated homocysteine levels. Proper management of celiac disease with a gluten-free diet & appropriate supplementation can help address these nutritional concerns, especially in individuals with MTHFR mutations. Either way me purchasing this supplement may have led me to find the root cause of my ailments which is what i have been on the hunt to find the answers for. I truly believe I have found it. Now, Some doctors do care however, the majority are dangerous because they only feed you band-aid medications, guilt & shame instead of helping you find real solutions to your problems. Again this is MY PERSONAL EXPERIENCE & but i hope it may help somebody else ♥️ #triquetra #MTHFR #folate #methylfolate #supplement #b9 #b12 #nutrientdeficiency #celiacdisease #glutenfree